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Im using GUIMiner and want to mine Scrypt with some high end GTX GPUs but im always getting ""No valid shares yet..."" even after an hour what can I do about it?
Scrypt isn't a good algorithm for GPU mining. The algorithm was taken over by ASICs, and you can earn less than a tenth of a cent per day by mining scrypt, if you ever find a share on that algorithm.
Instead, I suggest that you mine an algorithm where GPUs can be profitable. Ethash is an example of an algorithm where both GPUs and ASICs can both be competitive.